Protease Inhibitors (PIs) for HIV
Some of these medicines must be used with ritonavir.
How It Works
Protease inhibitors (PIs) are antiretroviral medicines. They prevent HIV from multiplying, reducing the amount of virus in your body. When the amount of virus in the blood is kept at a minimum, the immune system has a chance to recover and grow stronger.
Why It Is Used
The use of three or more antiretroviral medicines (antiretroviral therapy), or ART) is the usual treatment for HIV infection.
The combination of medicines used for ART will depend on your health, other conditions you might have (such as hepatitis), and results of testing. Talk to your doctor about the best treatment plan for you.
Medical experts recommend that people begin treatment for HIV as soon as they know that they are infected.1, 2 Treatment is especially important for pregnant women, people who have other infections (such as tuberculosis or hepatitis), and people who have symptoms of AIDS.
You may also want to start HIV treatment if your sex partner does not have HIV. Treatment of your HIV infection can help prevent the spread of HIV to your sex partner.3
The U.S. National Institutes of Health recommend one of the following programs for people who begin treatment for HIV:3
How Well It Works
Antiretroviral therapy can also decrease symptoms of HIV infection, such as fever and weakness, and help the person gain weight.
The rate at which antiretrovirals decrease viral loads is affected by:3
All medicines have side effects. But many people don't feel the side effects, or they are able to deal with them. Ask your pharmacist about the side effects of each medicine you take. Side effects are also listed in the information that comes with your medicine.
Here are some important things to think about:
Call your doctor if you have:
Common side effects of these medicines include:
To prevent serious medicine interactions or a decrease in medicine effectiveness, be sure to learn which medicines should not be taken with PIs and other antiretroviral medicines.
Indinavir causes kidney stones in a small number of people who use it. The risk of kidney stones can be reduced by drinking at least 48 fl oz (1.4 L) of fluid each day.
Side effects of any combination medicine can include the side effects of any of the single medicines in the combination.
Report all side effects to your doctor at your next visit. He or she can adjust your dose or give you other medicines to reduce side effects. Some mild side effects, such as nausea, improve as your body adjusts to the medicine.
Many people think antiretroviral medicines always have severe side effects. In fact, only a few people experience severe or dangerous side effects.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
Food increases the absorption of atazanavir, nelfinavir, and darunavir.5 Certain acid-reducing medicines, such as omeprazole or famotidine, should not be taken at the same time as atazanavir. Before you take protease inhibitors (PIs), be sure to tell your doctor about any other medicines you are taking.
Resistance to PIs develops more frequently if these medicines are used alone or are not taken exactly as prescribed.
Lopinavir is combined with a low dose of ritonavir to inhibit the breakdown of lopinavir in the body. This delayed breakdown of lopinavir increases its effectiveness.
PIs are expensive. They can cost up to two times more than nucleoside/nucleotide reverse transcriptase inhibitors (NNRTIs).
Things to think about when choosing a combination of medicines include:
Do not use the nonprescription herbal supplement St. John's wort while you are taking a protease inhibitor, because St. John's wort can interfere with how well these medicines work.
Talk to your doctor about whether you can eat grapefruit or drink grapefruit juice while you are taking protease inhibitors. It may increase the side effects of some of these medicines.6
Medicine is one of the many tools your doctor has to treat a health problem. Taking medicine as your doctor suggests will improve your health and may prevent future problems. If you don't take your medicines properly, you may be putting your health (and perhaps your life) at risk.
There are many reasons why people have trouble taking their medicine. But in most cases, there is something you can do. For suggestions on how to work around common problems, see the topic Taking Medicines as Prescribed.
Advice for women
If you are pregnant, breast-feeding, or planning to get pregnant, do not use any medicines unless your doctor tells you to. Some medicines can harm your baby. This includes prescription and over-the-counter medicines, vitamins, herbs, and supplements. And make sure that all your doctors know that you are pregnant, breast-feeding, or planning to get pregnant.
Follow-up care is a key part of your treatment and safety. Be sure to make and go to all appointments, and call your doctor if you are having problems. It's also a good idea to know your test results and keep a list of the medicines you take.
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