Alpha-Blockers for Benign Prostatic Hyperplasia
How It Works
Alpha-blockers help treat benign prostatic hyperplasia (BPH) by relaxing smooth muscle tissue found in the prostate and the bladder neck. This allows urine to flow out of the bladder more easily.
These medicines usually are taken by mouth once or twice a day.
Why It Is Used
These medicines often are used by men who have moderate and bothersome symptoms of prostate enlargement and who want more than home treatment for their symptoms.
How Well It Works
Many BPH symptoms improve with alpha-blockers.1 For improving symptoms and urine flow, taking these medicines works better than taking no medicine. Men may have about a 4-point reduction in their American Urological Association (AUA) symptom index score.2
Symptoms typically improve in 2 to 3 weeks.
Using a combination of an alpha-blocker with a 5-alpha reductase inhibitor long-term may help your symptoms more than either medicine alone.3
Side effects vary with the medicine and the individual. Common minor side effects of alpha-blockers include:
Alpha-blockers may cause ejaculation of semen into the bladder (retrograde ejaculation) instead of out through the penis. This is not harmful.
These side effects go away when the medicine is stopped.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
If you plan surgery for cataracts, make sure your doctors know that you take alpha-blockers. Some of these medicines have been linked to a problem called intra-operative floppy iris syndrome (IFIS).
Fewer side effects, especially low blood pressure when standing up suddenly, may occur if the drug is taken at bedtime.
Alpha-blockers are sometimes used to treat high blood pressure too. But for some people, an alpha-blocker does not help with their high blood pressure or is not a good choice for other reasons. So even if you are taking an alpha-blocker for your BPH symptoms, you may have to take another medicine to control your high blood pressure.
eMedicineHealth Medical Reference from Healthwise
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