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Melanoma Treatment (Patient) (cont.)

Treatment Options by Stage

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Stage 0 (Melanoma in Situ)

Treatment of stage 0 is usually surgery to remove the area of abnormalcells and a small amount of normal tissue around it.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage 0 melanoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Stage I Melanoma

Treatment of stage I melanoma may include the following:

  • Surgery to remove the tumor and some of the normal tissue around it.
  • A clinical trial of surgery to remove the tumor and some of the normal tissue around it, with or without lymph node mapping and lymphadenectomy.
  • A clinical trial of new techniques to detect cancercells in the lymph nodes.
  • A clinical trial of lymphadenectomy with or without adjuvant therapy.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage I melanoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Stage II Melanoma

Treatment of stage II melanoma may include the following:

  • Surgery to remove the tumor and some of the normal tissue around it, followed by removal of nearby lymph nodes.
  • Lymph node mapping and sentinel lymph node biopsy, followed by surgery to remove the tumor and some of the normal tissue around it. If cancer is found in the sentinel lymph node, a second surgery may be done to remove more nearby lymph nodes.
  • Surgery followed by high-dosebiologic therapy.
  • A clinical trial of adjuvantchemotherapy and/or biologic therapy.
  • A clinical trial of new techniques to detect cancer cells in the lymph nodes.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage II melanoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Stage III Melanoma

Treatment of stage III melanoma may include the following:

  • Surgery to remove the tumor and some of the normal tissue around it.
  • Surgery to remove the tumor with skin grafting to cover the wound caused by surgery.
  • Surgery followed by biologic therapy.
  • A clinical trial of surgery followed by chemotherapy and/or biologic therapy.
  • A clinical trial of biologic therapy.
  • A clinical trial comparing surgery alone to surgery with biologic therapy.
  • A clinical trial of chemoimmunotherapy or biologic therapy.
  • A clinical trial of hyperthermicisolated limb perfusion using chemotherapy and biologic therapy.
  • A clinical trial of biologic therapy and radiation therapy.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage III melanoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Stage IV Melanoma

Treatment of stage IV melanoma may include the following:

  • Surgery or radiation therapy as palliative therapy to relieve symptoms and improve quality of life.
  • Chemotherapy and/or biologic therapy.
  • A clinical trial of new chemotherapy, biologic therapy, and/or targeted therapy with monoclonal antibodies, or vaccine therapy.
  • A clinical trial of radiation therapy as palliative therapy to relieve symptoms and improve quality of life.
  • A clinical trial of surgery to remove all known cancer.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage IV melanoma and recurrent melanoma. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

eMedicineHealth Public Information from the National Cancer Institute

This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http://cancer.gov or call 1-800-4-CANCER

This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

Some material in CancerNet™ is from copyrighted publications of the respective copyright claimants. Users of CancerNet™ are referred to the publication data appearing in the bibliographic citations, as well as to the copyright notices appearing in the original publication, all of which are hereby incorporated by reference.






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