Adult Acute Lymphoblastic Leukemia Treatment (Professional) (cont.)
IN THIS ARTICLE
Stage Information for Adult ALL
There is no clear-cut staging system for this disease. This disease is classified as untreated, in remission, or recurrent.
Untreated Adult ALL
For a newly diagnosed patient with no prior treatment, untreated adult ALL is defined by the following:
Adult ALL in Remission
A patient who has received remission-induction treatment of ALL is in remission if all of the following criteria are met:
Treatment Option Overview
Successful treatment of ALL consists of the control of bone marrow and systemic disease and the treatment (or prevention) of sanctuary-site disease, particularly the central nervous system (CNS).[1,2] The cornerstone of this strategy includes systemically administered combination chemotherapy with CNS preventive therapy. CNS prophylaxis is achieved with chemotherapy (intrathecal and/or high-dose systemic therapy) and, in some cases, cranial radiation therapy.
Treatment is divided into the following three phases:
The average length of treatment for ALL varies between 1.5 and 3 years in the effort to eradicate the leukemic cell population. Younger adults with ALL may be eligible for selected clinical trials for childhood ALL. (Refer to the PDQ summary on Childhood Acute Lymphoblastic Leukemia Treatment for more information.)
Entry into a clinical trial is highly desirable to assure adequate patient treatment and maximal information retrieval from the treatment of this highly responsive, but usually fatal, disease.
Table 2. Standard Treatment Options for Adult ALL
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