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Uterine Sarcoma Treatment (Professional) (cont.)

Cellular Classification of Uterine Sarcoma

The most common histologic types of uterine sarcomas are:

  • Carcinosarcomas (mixed mesodermal sarcomas [40%–50%]).
  • Leiomyosarcomas (30%).
  • Endometrial stromal sarcomas (15%).

The uterine neoplasm classification of the International Society of Gynecologic Pathologists and the World Health Organization uses the term carcinosarcomas for all primary uterine neoplasms containing malignant elements of both epithelial and stromal light microscopic appearances, regardless of whether malignant heterologous elements are present.[1]


  1. Silverberg SG, Major FJ, Blessing JA, et al.: Carcinosarcoma (malignant mixed mesodermal tumor) of the uterus. A Gynecologic Oncology Group pathologic study of 203 cases. Int J Gynecol Pathol 9 (1): 1-19, 1990.

Stage Information for Uterine Sarcoma

The FIGO staging for carcinoma of the corpus uteri has been applied to uterine sarcoma.[1]

Stage I

Stage I sarcoma is confined to the corpus uteri. This stage accounts for 50% of all presentations.

  • Stage IA: tumor limited to endometrium.
  • Stage IB: invasion to less than 50% of the myometrium.
  • Stage IC: invasion to more than 50% of the myometrium.

Stage II

Stage II uterine sarcoma means the cancer has involved the corpus and the cervix but has not extended outside the uterus.

  • Stage IIA: endocervical glandular involvement only.
  • Stage IIB: cervical stromal invasion.

Stage III

Stage III uterine sarcoma means extension outside of the uterus but confined to the true pelvis.

  • Stage IIIA: tumor invades serosa and/or adnexae and/or positive peritoneal cytology.
  • Stage IIIB: metastases to pelvic and/or para-aortic lymph nodes.

Stage IV

Stage IV uterine sarcoma means involvement of the bladder or bowel mucosa or metastasis to distant sites.

  • Stage IVA: tumor invasion of bladder and/or bowel mucosa.
  • Stage IVB: distant metastases, including intra-abdominal and/or inguinal lymph nodes.


  1. Shepherd JH: Revised FIGO staging for gynaecological cancer. Br J Obstet Gynaecol 96 (8): 889-92, 1989.
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