Definition of Scleroderma
Scleroderma: A disease of connective tissue that causes scar tissue (fibrosis) to form in the skin and sometimes also in other organs of the body. Scleroderma is classified into diffuse and limited forms. Diffuse scleroderma affects many internal and external areas of the body, including the skin of the entire body, the bowels, and the lungs. Limited scleroderma affects only certain body sections. The CREST syndrome is the most common limited form of scleroderma. CREST stands for
The cause of scleroderma is unknown. There is some evidence that genes play at least a partial role in causing the disease. The immune system plays a central role in the disease process. It is not unusual to find other autoimmune diseases in families of scleroderma patients. The treatment of scleroderma is directed toward the particular organ system that is causing symptoms. The disease occurs more frequently in females than in males.Source: MedTerms™ Medical Dictionary
Last Editorial Review: 3/19/2012
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