Restless legs syndrome is a condition caused by uncomfortable sensations that produce an intense, often irresistible urge to move. This can lead to sleep disturbance and severe fatigue that interferes with daily activities.

Restless legs syndrome is felt most often in the legs. But it can affect the arms, the torso, or a phantom limb. These sensations are described as "pins and needles," prickling, creeping, crawling, tingling, and sometimes painful. They most often occur in the evening when the person is attempting to relax or sleep. Moving can temporarily relieve these sensations.

The cause of this syndrome is often not known. Certain drugs (such as antidepressants), pregnancy, or iron deficiency or related anemia can trigger it.

Restless legs syndrome can be treated with drugs such as those that increase the brain chemical dopamine (levodopa or dopamine agonists), pain medicines (opioids), or anticonvulsants (gabapentin) to control leg movements and assist with sleep.