Leucovorin comes in intravenous (IV), intramuscular (IM) injection (shot), and oral form.
How It Works
Why It Is Used
Leucovorin is used with either methotrexate (MTX) for the treatment of ectopic pregnancy or fluorouracil (5-FU) for cancer treatment.
How Well It Works
Most of the complications and side effects of methotrexate can be either prevented or treated by using leucovorin, which is usually given 24 hours after the methotrexate is given.
Leucovorin enhances the binding of fluorouracil (5-FU) and prolongs the life span of 5-FU, increasing the anticancer effect.1
Leucovorin is very well tolerated and has almost no side effects of its own.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
Leucovorin generally decreases the severity of side effects of MTX. It can increase the severity of the side effects of 5-FU when used with that medicine.
Leucovorin should be administered only under the supervision of a medical oncologist.
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