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Cevimeline for Sjögren's Syndrome


Generic NameBrand Name

Evoxac is given orally as a 30 mg capsule. Dosages vary from 1 to 3 capsules a day.

How It Works

Cevimeline stimulates the moisture-producing glands to increase saliva and tear production over a sustained period of time.

Why It Is Used

Cevimeline is used to treat symptoms of dry mouth and eyes caused by Sjögren's syndrome.

You should not take cevimeline if you have:

  • Uncontrolled asthma.
  • Narrow-angle glaucoma or inflammation of the iris.

How Well It Works

Studies show that cevimeline improves symptoms of dry mouth and eyes.1

Side Effects

Side effects from cevimeline may include:

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Talk to your doctor before taking cevimeline if you have:

If you are breast-feeding, pregnant, or trying to become pregnant, talk to your doctor before taking cevimeline.

Before taking cevimeline, review with your doctor all medicines that you take, both prescription and nonprescription.

Complete the new medication information form (PDF)Click here to view a form.(What is a PDF document?) to help you understand this medication.



  1. Petrone D, et al. (2002). A double-blind, randomized, placebo-controlled study of cevimeline in Sjögren's syndrome patients with xerostomia and keratoconjunctivitis sicca. Arthritis and Rheumatism, 46(3): 748–754.


ByHealthwise Staff
Primary Medical ReviewerAnne C. Poinier, MD - Internal Medicine
Specialist Medical ReviewerStanford M. Shoor, MD - Rheumatology
Last RevisedMay 4, 2010

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