Definition of Genoplasty

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Genoplasty: A technology that uses the repair mechanisms normally present in cells to repair gene defects.

In genoplasty, a short oligonucleotide fragment is introduced into the cell to simulate a normal DNA sequence and this deceives the cell into repairing itself. The sequence of the gene itself is thus changed permanently.

Genoplasty is different from gene therapy in which a normal gene is inserted into the cell.