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Definition of Y-linkage

Y-linkage: The presence of a gene on the Y chromosome. Y-linkage is analogous to X-linkage (the presence of a gene on the X chromosome) in that it says a gene is on one of the sex chromosomes.

It has often been said that little is known about Y-linkage. This is no longer true. As of the year 2012, about 3 dozen genes were known to be Y-linked including:

  • ASMTY (which stands for acetyl serotonin methyltransferase),
  • TSPY (testis-specific protein),
  • IL3RAY (interleukin-3 receptor),
  • SRY (sex-determining region),
  • TDF (testis determining factor),
  • ZFY (zinc finger protein), PRKY (protein kinase, Y-linked),
  • AMGL (amelogenin),
  • CSF2RY (granulocyte-macrophage colony-stimulating factor receptor, alpha subunit on the Y chromosome),
  • ANT3Y (adenine nucleotide translocator-3 on the Y),
  • AZF2 (azoospermia factor 2),
  • BPY2 (basic protein on the Y chromosome),
  • AZF1 (azoospermia factor 1),
  • DAZ (deleted in azoospermia),
  • RBM1 (RNA binding motif protein, Y chromosome, family 1, member A1),
  • RBM2 (RNA binding motif protein 2) and
  • UTY (ubiquitously transcribed TPR gene on Y chromosome).

Source: MedTerms™ Medical Dictionary
http://www.medicinenet.com/script/main/art.asp?articlekey=15729
Last Editorial Review: 9/20/2012

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