Definition of Mutation, hereditary
Mutation, hereditary: A heritable change in the DNA of a gene or chromosome in a cell destined to become an egg or a sperm or the zygote (the conceptus) at the single-cell stage. When transmitted to a child, an hereditary mutation is incorporated in every cell of their body.
Hereditary mutations play a key role in genetic diseases. They also play a role in certain types of cancer as, for example, the eye tumor retinoblastoma and Wilms tumor, a childhood malignancy of the kidney.
Hereditary mutations are also called germline mutations.Source: MedTerms™ Medical Dictionary
Last Editorial Review: 6/14/2012
Medical Dictionary Definitions A - Z
Search Medical Dictionary
- Early Care for Your Premature Baby
- What to Eat When You Have Cancer
- When to Take More Pain Medication