Definition of Booster shotBooster shot: An additional dose of a vaccine needed periodically to 'boost' the immune system. For example, a booster shot of the tetanus and diphtheria (Td) vaccine is recommended for adults every 10 years. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=20418 Last Editorial Review: 3/19/2012
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