Definition of Y chromosome infertility

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Y chromosome infertility: Male infertility with oligozoospermia (a subnormal number of sperm) or azoospermia (the absence of sperm) caused by deletion or rearrangement of the long arm of the Y chromosome, as demonstrated by chromosome analysis or by molecular studies which may show microdeletions (of region AZFa, AZFb, or AZFc) of the Y chromosome. Y chromosome infertility is considered as a diagnostic possibility when an otherwise healthy male proves to be infertile.