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Definition of Dihydroorotate dehydrogenase

Dihydroorotate dehydrogenase: An enzyme necessary to pyrimidine synthesis and therefore essential to the production of DNA and RNA. The drug leflunomide (Arava), an immunomodulatory agent, acts by specifically inhibiting dihydroorotate dehydrogenase.

Source: MedTerms™ Medical Dictionary
http://www.medicinenet.com/script/main/art.asp?articlekey=23199
Last Editorial Review: 6/14/2012

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