Medical Definition of Toll-like receptor 4
Toll-like receptor 4: TLR4. One in a family of receptors that provide critical links between immune stimulants produced by microorganisms and the initiation of host defenses. Abbreviated TLR4.
TLR4 is a transmembrane lipopolysaccharide receptor. Activation of it causes the release of antimicrobial peptides, inflammatory cytokines and chemokines, and costimulatory molecules that initiate the innate immune response to common gram-negative bacteria. TLR4 also interacts with respiratory syncytial virus, heat-shock proteins, fibronectin, fibrinogen, and hyaluronic acid.Source: MedTerms™ Medical Dictionary
Last Editorial Review: 9/14/2016
Medical Dictionary Definitions A - Z
Search Medical Dictionary
- What Is Inherited Lipodystrophy?
- Do You Take Good Care of Your Eyes?
- Tips for a Clean Home & Healthy Cat