Definition of Agitated depressionAgitated depression: A major depressive disorder with restlessness and motor excitement. Agitated depression was once called melancholia agitata. It is now also known as mixed mania. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=24365 Last Editorial Review: 6/14/2012
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