Definition of CNS prophylaxisCNS prophylaxis: Chemotherapy or radiation therapy to the central nervous system (CNS) as a preventive treatment. CNS prophylaxis is given to kill cancer cells that may be in the brain and spinal cord, even though no cancer has been detected there. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=2766 Last Editorial Review: 3/19/2012
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