Definition of Defect, atrial septal (ASD)Defect, atrial septal (ASD): A hole in the septum, the wall, between the atria, the upper chambers of the heart. Commonly called an ASD. ASDs are a major class of congenital cardiac malformation. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=2916 Last Editorial Review: 6/14/2012
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