Definition of UROD
UROD: Uroporphyrinogen decarboxylase, an enzyme required for the synthesis of heme, a part of the hemoglobin molecule. UROD catalyses the decarboxylation of uroporphyrinogen III to coproporphyrinogen III by the conversion of four acetic acid groups to four methyl groups.
The gene encoding UROD is in chromosome region 1p34. Mutations in this gene resulting in reduced activity of the enzyme cause the most common form of porphyria -- porphyria cutanea tarda (PCT) -- and the recessively inherited form of hepatoerythropoietic porphyria (HEP).
See also: UROD deficiency.Source: MedTerms™ Medical Dictionary
Last Editorial Review: 10/9/2012
Medical Dictionary Definitions A - Z
Search Medical Dictionary
Find out what women really need.
Most Popular Topics
Pill Identifier on RxList
- quick, easy,
Find a Local Pharmacy
- including 24 hour, pharmacies