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Definition of Amyotrophic lateral sclerosis 1

Amyotrophic lateral sclerosis 1: ALS1. A form of amyotrophic lateral sclerosis (ALS) inherited in an autosomal dominant manner and caused by mutation in the superoxide dismutase-1 gene (SOD1) on chromosome 21q22.1. About 15 to 20% of familial ALS is type 1 (ALS1). Sporadic cases of ALS are sometimes due to new mutation in the SOD1 gene.

Source: MedTerms™ Medical Dictionary
http://www.medicinenet.com/script/main/art.asp?articlekey=34048
Last Editorial Review: 6/14/2012

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