Definition of Charley horseCharley horse: Slang for a cramp in a muscle in the leg, usually caused by a strain or injury. A charley horse can last anywhere from a few seconds to over a quarter of an hour. It is not uncommon for one to recur before it finally resolves. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=34344 Last Editorial Review: 3/19/2012
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