Definition of HepatomegalyHepatomegaly: An abnormally enlarged liver. Hepatomegaly can be caused by heart failure, blockage of blood vessels from the liver, or be a sign of chronic liver disease. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=3715 Last Editorial Review: 3/19/2012
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