Definition of BMPR1A

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BMPR1A: A gene located on chromosome 10 in band 10q22.3 that encodes bone morphogenic protein receptor 1A, a kinase receptor that is involved in bone morphogenetic protein (BMP) signaling. Mutations in BMPR1A account for 25% to 40% of cases of juvenile polyposis, an autosomal dominant gastrointestinal polyposis syndrome in which patients are at risk for developing gastrointestinal cancers.