Definition of KetoneKetone: A chemical substances that the body makes when it does not have enough insulin in the blood. When ketones build up in the body for a long time, serious illness or coma can result. See: Diabetic ketoacidosis; Ketoacidosis. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=39574 Last Editorial Review: 10/9/2012
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