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Definition of Loss-of-function mutation

Loss-of-function mutation: A mutation that results in reduced or abolished protein function. Gain-of-function mutations,which are much less common, confer an abnormal activity on a protein.

Source: MedTerms™ Medical Dictionary
http://www.medterms.com/script/main/art.asp?articlekey=39612
Last Editorial Review: 6/14/2012

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