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Definition of Simian crease

Simian crease: A single transverse crease in the palm, a minor variation associated with Down syndrome (trisomy 21) and a number of chromosomal and other abnormalities. Also called a four-finger crease; single palmar flexion crease; single upper palm crease.

Source: MedTerms™ Medical Dictionary
Last Editorial Review: 3/19/2012

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