Definition of MacrocephalyMacrocephaly: An abnormally large head. The opposite of macrocephaly is microcephaly. Macrocephaly can be a normal variant or be a sign of pressure within the growing head during childhood, such as from hydrocephalus. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=4235 Last Editorial Review: 3/19/2012
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