Definition of MacroglossiaMacroglossia: An abnormally large tongue. Macroglossia is sometimes said to be associated with Down syndrome, but in that disorder the tongue is actually large only in relationship to a smaller-than-normal mouth cavity. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=4237 Last Editorial Review: 3/19/2012
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