Definition of Major histocompatibility complexMajor histocompatibility complex: Abbreviated MHC. A cluster of genes located on chromosome 6 concerned with antigen production and critical to the success of transplantation. The MHC includes the human leukocyte antigen (HLA) genes. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=4249 Last Editorial Review: 6/14/2012
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