Definition of NucleosomeNucleosome: A structure that is responsible in part for the compactness of a chromosome. Each nucleosome consists of a sequence of DNA wrapped around a core of histone, which is a type of protein. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=4595 Last Editorial Review: 3/19/2012
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