Definition of Soft tissue sarcomaSoft tissue sarcoma: A malignant tumor that begins in the muscle, fat, fibrous tissue, blood vessels, or other "soft" supporting tissues of the body. Soft tissue sarcomas do not originate in bone or cartilage. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=5517 Last Editorial Review: 6/14/2012
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