Definition of VestibuleVestibule: In medicine and dentistry, a space or cavity at the entrance to a canal, channel, tube, or vessel. For instance, the front of the mouth is a vestibule. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=6134 Last Editorial Review: 3/19/2012
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