Definition of PathognomonicPathognomonic: A sign or symptom that is so characteristic of a disease that it can be used to make a diagnosis. For example, Koplik spots in the mouth opposite the first and second upper molars are pathognomonic of measles. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=6386 Last Editorial Review: 3/19/2012
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