Definition of Homo-Homo-: Prefix meaning same, as in homology (similarity in DNA or protein sequences between individuals or between species) and homosexual (a person who is sexually attracted to persons of the same sex). The opposite of homo- is hetero-. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=7319 Last Editorial Review: 3/19/2012
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