Definition of AntagonistAntagonist: A substance that acts against and blocks an action. Antagonist is the opposite of agonist. Antagonists and agonists are key players in the chemistry of the human body and in pharmacology. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=7836 Last Editorial Review: 3/19/2012
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