Definition of Thrombinogen

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Thrombinogen: Better known today as prothrombin, a coagulation (clotting) factor needed for the normal clotting of blood.

There is a cascade of biochemical events that leads to the formation of the final clot. In this cascade, prothrombin is a precursor to thrombin. Because prothrombin comes before thrombin, it is called prothrombin.

The prothrombin time is a clotting test. a test done to test the integrity of part of the clotting scheme. Familiarly called the "pro time," the test is the time needed for clot formation after a substance called thromboplastin (+ calcium) has been added to plasma.