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Definition of Pregnancy, dangerous drugs during

Pregnancy, dangerous drugs during: A teratogen is an agent that can disturb the development of the embryo or fetus. Teratogens halt the pregnancy or produce a congenital malformation (a birth defect). Classes of teratogens include radiation, maternal infections, chemicals, and drugs.

Drugs that are capable of acting as teratogens include:

  • ACE (angiotensin converting enzyme) inhibitors such as:
    • benazepril (LOTENSIN),
    • captopril (CAPOTEN),
    • enalapril (VASOTEC),
    • fosinopril sodium (MONOPRIL),
    • lisinopril (ZESTRIL, PRINIVIL),
    • lisinopril + hydrochlorothiazide (ZESTORETIC, PRINZIDE),
    • quinapril (ACCUPRIL) and
    • ramipril (ALTACE).
  • Acne medication isotretinoin (ACCUTANE, RETIN-A).
  • Alcohol -- increases the risk of a stillbirth and the Fetal Alcohol Syndrome.
  • Androgens (male hormones).
  • Antibiotics tetracycline (ACHROMYCIN), and doxycycline (VIBRAMYCIN), and streptomycin.
  • Anticoagulant (blood-thinner) warfarin (COUMADIN).
  • Anticonvulsants (seizure medications) such as:
    • phenytoin (DILATIN),
    • valproic acid (DEPAKENE, VALPROTATE),
    • trimethadione (TRIDIONE),
    • paramethadione (PARADIONE), and
    • carbamazepine (TEGRETOL).
  • Anti-depressant drug lithium (ESKALITH, LITHOB).
  • Antimetabolite/anticancer drugs methotrexate (RHEUMATREX) and aminopterin.
  • Antirheumatic agent and metal-binder (chelator) penicillamine (CIPRIMENE, DEPEN).
  • Antithyroid drugs such as:
    • thiouracil/propylthiouracil and
    • carbimazole/methimazole.
  • Cocaine.
  • DES (diethylstilbestrol), a hormone.
  • Thalidomide (THALOMID) which was approved by the FDA for the treatment of a complication of leprosy (erythema nodosum leprosum).

Source: MedTerms™ Medical Dictionary
http://www.medicinenet.com/script/main/art.asp?articlekey=9333
Last Editorial Review: 6/14/2012

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