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Definition of Teratogenic drugs

Teratogenic drugs: A teratogen is an agent that can disturb the development of the embryo or fetus. Teratogens halt the pregnancy or produce a congenital malformation (a birth defect). Classes of teratogens include radiation, maternal infections, chemicals, and drugs.

Drugs that are capable of acting as teratogens include:

  • ACE (angiotensin converting enzyme) inhibitors such as:
    • benazepril (Lotensin),
    • captopril (Capoten),
    • enalapril (Vasotec),
    • fosinopril sodium (Monopril),
    • lisinopril (Zestril, Prinivil),
    • lisinopril + hydrochlorothiazide (Zestoretic, Prinzide),
    • quinapril (Accupril) and
    • ramipril (Altace).
  • Acne medication isotretinoin (Accutane, Retin-A).
  • Alcohol ingested chronically or in binges.
  • Androgens (male hormones).
  • Antibiotics tetracycline (Achromycin), and doxycycline (Vibramycin), and streptomycin.
  • Anticoagulant (blood-thinner) warfarin (Coumadin).
  • Anticonvulsants (seizure medications) such as:
    • phenytoin (Dilatin),
    • valproic acid (Depakene, Valprotate),
    • trimethadione (Tridione),
    • paramethadione (Paradione), and
    • carbamazepine (Tegretol).
  • Anti-depressant drug lithium (Eskalith, Lithob).
  • Antimetabolite/anticancer drugs methotrexate (Rheumatrex) and aminopterin.
  • Antirheumatic agent and metal-binder (chelator) penicillamine (Ciprimene, Depen).
  • Antithyroid drugs such as:
    • thiouracil/propylthiouracil and
    • carbimazole/methimazole.
  • Cocaine.
  • DES (diethylstilbestrol), a hormone.
  • Thalidomide (Thalomid) which was approved by the FDA for the treatment of a complication of leprosy (erythema nodosum leprosum).

Source: MedTerms™ Medical Dictionary
http://www.medicinenet.com/script/main/art.asp?articlekey=9334
Last Editorial Review: 6/14/2012

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