Definition of Antidepressant, MAOIAntidepressant, MAOI: Monoamine oxidase inhibitor (MAOI), a potent class of medications used to treat depression. This group of antidepressants have many serious drug interactions, which may limit their use. Source: MedTerms™ Medical Dictionaryhttp://www.medterms.com/script/main/art.asp?articlekey=9981 Last Editorial Review: 9/20/2012
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