Shingles (also termed herpes zoster) is a disease caused by reactivation of the herpes zoster virus (varicella-zoster virus, or VZV) that results in a painful localized skin rash, usually with blisters (fluid filled sacks) on top of the reddish skin. This same virus causes the childhood illness chickenpox. The chickenpox virus (varicella) remains in a dormant state in the body in the root of nerves that control sensation. In about one out of five people, the virus "wakes up," often many years after the chickenpox infection. The virus then travels along a sensory nerve into the skin and causes shingles. The majority of patients who get shingles are over the age of 60; it infrequently occurs in younger people. Investigators estimate that about 1 million cases of shingles occur per year in the U.S.
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Herpes zoster (shingles) is 1 of 2 distinctive manifestations of human infection with the varicella-zoster virus (VZV), the other being varicella (chickenpox).
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