No one knows for sure what causes the chickenpox virus to become reactivated to cause shingles. Some investigators suggest that the following conditions may participate in virus reactivation, but this lists only some of the major conditions that may trigger reactivation:
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Herpes zoster (shingles) is 1 of 2 distinctive manifestations of human infection with the varicella-zoster virus (VZV), the other being varicella (chickenpox).
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