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Sjögren Syndrome

Sjögren Syndrome Overview

Sjögren syndrome is a disorder of the moisture-producing glands, such as the tear ducts and the salivary glands. These glands become infiltrated with white blood cells (lymphocytes) that are part of our immune system. This causes the glands to produce less moisture, leading to dryness. In some cases, lymphocytes also infiltrate internal organs, causing organ dysfunction and a wide variety of symptoms.

Sjögren syndrome often occurs in people who have other rheumatic disorders such as rheumatoid arthritis, systemic lupus erythematosus or scleroderma, or polymyositis/dermatomyositis. This is described as secondary Sjögren syndrome. The syndrome also can occur without another disorder, in which case it is called primary Sjögren syndrome.

Sjögren syndrome affects 0.1-3% of the population of the United States. The condition is found throughout the world and in all ethnic groups. While Sjögren syndrome can strike anyone, it most often affects middle-aged and elderly women.