What Is Lupus?
Lupus is a classic autoimmune disease whereby a misdirected immune system leads to inflammation and injury to one's own body tissues. Lupus can involve the skin, joints, and internal organs. The heart, lungs, and kidneys can also be affected in some patients. There is no specific cure, but treatments are effective at minimizing damage and improving function. Approximately 80% of lupus patients are women.
Symptoms of Lupus: Joint Pain
Though the first signs of lupus can be rash, they are often pains in the muscles and joints. Both sides of the body tend to be affected. Hands, wrists, knees, and feet are commonly affected. The joints can become swollen, warm, and have limited range of motion.
Symptoms of Lupus: Butterfly Rash
A classic rash of lupus involves the cheeks and bridge of the nose. This is referred to as a "butterfly-shaped" rash. It is also common for the skin to be very sensitive to burning and irritation after sun exposure. This is referred to as photosensitivity.
Symptom of Lupus: Nail Changes
Lupus rash can cause a ruddy discoloration of the backs of the hands and fingers. There can also be poor circulation to the nail beds that leads to irregularities of the fingernails. Inflammation at the nail bed can cause swelling and puffiness.
Symptoms of Lupus: Fever and Fatigue
Fatigue is one of the most common symptoms of lupus. It can interfere with daily activities, exercise, and occupation. Low-grade fever is not uncommon during disease flares and can be a warning sign for an impending flare-up of lupus.
Symptoms of Lupus: Light Sensitivity
Sensitivity to sun exposure is very common in lupus. It can cause the skin to become seriously irritated. Sun exposure can also flare the disease internally in some patients. Certain medications can make lupus patients even more sensitive to sunlight.
Symptoms of Lupus: Hair Loss
Symptoms of lupus tend to wax and wane. Depending on the type of lupus, skin inflammation (dermatitis) hair loss can be temporary or permanent. Fortunately, permanent hair loss is less common than temporary hair thinning that recovers after a disease flare.
Symptoms of Lupus: Raynaud's Phenomenon
Raynaud's phenomenon is a condition whereby fingers and/or toes become purplish and sometimes painful and numb in response to emotional stress or cold temperature exposure. These situations lead to spasm and restricted circulation. Some patients with lupus have Raynaud's phenomenon.
Is It Really Lupus?
Initially, lupus that affects the joints can mimic rheumatoid arthritis. Rheumatoid arthritis can also cause fatigue. The skin rash of lupus, however, is not seen in patients with rheumatoid arthritis. There are also specific lab tests that can help in distinguishing the diseases.
It can be challenging for doctors to diagnose lupus. Lupus can mimic other disease and its initial presentation varies from patient to patient. It is not unusual to have minor symptoms for years prior to diagnosis. There is no singular test for lupus. There are certain abnormal antibodies that can give clues to the diagnosis, including antinuclear antibodies (ANAs), deoxyribonucleic acid antibodies (anti DNAs), and anti-Smith antibodies. White and red blood counts can be low as can platelet counts. Sometimes tissue biopsies are necessary for diagnosis.
Who Can Get Lupus?
Lupus can affect people of either gender or any ethnic background. It affects women eight times as often as men. The onset is usually in the childbearing years. There is a higher prevalence in blacks, Latinos, and Afro-Caribbean individuals. There is a lower prevalence in Asians and whites. Lupus is more common in those who are related to someone known to have lupus.
Types of Lupus
Discoid lupus is a particular form of skin inflammation that can lead to scarring and permanent hair loss and can occur without systemic disease. A minority of systemic lupus patients have discoid skin changes. Drug-induced lupus is an immune response to certain medications and generally resolves when the medications are discontinued.
Medical Treatments for Lupus
While there is no cure for lupus, there are many effective treatments. These include topical steroid creams for skin rashes, nonsteroidal anti-inflammatory drugs (NSAIDs) for joint pain and fever, and antimalarial medications to help fight joint pain, ulcers, and rashes. Steroid medications taken by mouth, by injection, or intravenously are used to reduce inflammation of tissues. Medications that suppress the overactive immune system are used to treat severe lupus.
A number of disease-management options are available for patients to optimally care for themselves. These can be important and include covering up when out in sunlight, not smoking, exercising regularly, and minimizing stress. Adequate rest can be helpful, especially when the lupus is active.
Lupus and Kidney Issues
Lupus can affect organ function and cause permanent damage to the lungs, heart, kidneys, and other organs. Sometimes the organ injury is not apparent to those affected by lupus. The leading causes of death in patients with lupus are active disease, particularly kidney injury, infections, and cardiovascular disease.
Lupus and Heart Issues
Inflammation around the heart (pericarditis) is the most common heart ailment in lupus patients. This inflammation involves the natural sac around the heart and can cause severe chest pain that is worsened by changing body positions. Lupus patients also are prone to cardiovascular disease, including heart attacks from coronary artery disease. Other complications of lupus include heart valve disease and inflammation of heart muscle (myocarditis).
Lupus and Lung Issues
Inflammation of the tissue around the lungs is called pleuritis. Pleuritis affects approximately one-third of those with lupus at some time in their lives. Pleuritis leads to pain in the chest with deep breathing (pleurisy). Chest pain should be promptly evaluated by a doctor.
Lupus and Digestive Issues
Problems of the digestive system can be caused by disease of the liver or pancreas. This can lead to belly pain, difficulty swallowing, nausea, and vomiting. It can be a reaction to medications or from the lupus itself. Weight loss during flare-ups of the disease is common.
Lupus and Anemia
Anemia is a condition of abnormally low red blood cell counts. Anemia can be caused by lupus and medications used to treat it. Symptoms of anemia include fatigue and breathing difficulty, especially with exertion.
Lupus and the Nervous System
Lupus can affect the brain and nervous system. Symptoms range from headaches to numbness and tingling of the fingers and feet. Memory problems and thinking disturbances can occur. Though uncommon, lupus can cause strokes and seizures.
Lupus and Mental Health
Lupus patients are at risk for depression and anxiety. It is important for all those affected by mood changes to discuss these symptoms with the doctor. There are many treatments available to address these issues.
Lupus and Pregnancy
Lupus can increase the risk of miscarriage and other complications of pregnancy. The ideal time for women with lupus to become pregnant is when the disease is least active. Pregnant women with lupus can require high-risk obstetrics care. Optimizing medications and regular monitoring of lupus and the pregnancy is essential for pregnant women with lupus.
Babies born to women with lupus are generally healthy. Rarely, however, neonatal lupus can occur in the newborn. Neonatal lupus can cause skin rash or disturbance of the baby's heart rhythm. This can require special medications for the infant and even a temporary pacemaker to keep the heartbeat normalized.
Living With Lupus
Joint pain and fatigue from lupus can interfere with the ability to perform occupational duties. In the U.S., one- third of patients with such manifestations of lupus are unable to work. Patients may be required to reduce activities and can require assistance with child care. Nevertheless, a majority of patients with lupus can carry on normal daily activities.
Outlook for Lupus
With early aggressive treatments, most patients with lupus carry on with normal lives and are living longer than in the past. The keys to the outlook for each person affected by lupus is the severity of disease and whether or not vital organs are affected. The prognosis for most patients is very good.
Reviewed by Kirkwood Johnston, MD on Tuesday, May 03, 2016
Slideshow Pictures: Lupus -- Causes, Symptoms, Diagnosis and Treatments
This tool does not provide medical advice. See additional information: