The predominant cause of both small-cell lung cancer and non-small-cell lung cancer is tobacco smoking. However, small-cell lung cancer is more strongly linked to smoking than non-small-cell lung cancer.
All types of lung cancers occur with increased frequency in people who mine uranium, but small-cell lung cancer is most common. The prevalence is increased further in persons who smoke.
Exposure to radon (an inert gas that develops from the decay of uranium) has been reported to cause small-cell lung cancer.
Exposure to asbestos increases the risk of lung cancer by 9 times. A combination of asbestos exposure and cigarette smoking increases the risk by as much as 50 times.
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