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Sweet Orange

IN THIS ARTICLE

Are there any interactions with medications?



Celiprolol (Celicard)
Interaction Rating: Major Do not take this combination.

Consuming large amounts of sweet orange juice might decrease how much celiprolol (Celicard) the body absorbs. This might decrease how well celiprolol (Celicard) works. To avoid this interaction, separate taking this medication from consuming sweet orange by at least 4 hours.



Ivermectin
Interaction Rating: Major Do not take this combination.

Drinking sweet orange juice might decrease how much ivermectin the body absorbs. Taking sweet orange along with ivermectin might decrease the effectiveness of ivermectin.



Medications moved by pumps in cells (Organic anion-transporting polypeptide substrates)
Interaction Rating: Major Do not take this combination.

Some medications are moved by pumps in cells. Sweet orange might change how these pumps work and decrease how much of some medications get absorbed by the body. This could make these medications less effective. To avoid this interaction, separate taking these medications from consuming sweet orange by at least 4 hours.

Some of these medications that are moved by pumps in cells include bosentan (Tracleer), celiprolol (Celicard, others), etoposide (VePesid), fexofenadine (Allegra), fluoroquinolone antibiotics, glyburide (Micronase, Diabeta), irinotecan (Camptosar), methotrexate, paclitaxel (Taxol), saquinavir (Fortovase, Invirase), rifampin, statins, talinolol, torsemide (Demadex), troglitazone, and valsartan (Diovan).



Pravastatin (Pravachol)
Interaction Rating: Major Do not take this combination.

Drinking sweet orange juice might increase how much pravastatin (Pravachol) the body absorbs. Taking pravastatin (Pravachol) with sweet orange juice might increase drug levels in the body and possibly increase the chance of drug side effects.



Antibiotics (Quinolone antibiotics)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Calcium-fortified sweet orange juice can reduce the amount of some antibiotics the body absorbs. Reduced absorption of antibiotics can reduce their ability to fight infection. Sweet orange juice without calcium is unlikely to affect quinolone antibiotics.

Some quinolone antibiotics include ciprofloxacin (Cipro), enoxacin (Penetrex), gatifloxacin (Tequin), levofloxacin (Levaquin), lomefloxacin (Maxaquin), moxifloxacin (Avelox), norfloxacin (Noroxin), ofloxacin (Floxin), and trovafloxacin (Trovan).



Fexofenadine (Allegra)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Sweet orange might decrease how much fexofenadine (Allegra) the body absorbs. Taking sweet orange along with fexofenadine (Allegra) might decrease the effectiveness of fexofenadine (Allegra). To avoid this interaction, separate taking this medication from consuming sweet orange by at least 4 hours.



Medications moved by pumps in cells (P-Glycoprotein substrates)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Some medications are moved by pumps in cells. Sweet orange might change how these pumps work and change how much of some medications get absorbed by the body. There is not enough information to know how important this interaction might be. Until more is known, sweet orange juice should be used cautiously with medications moved by these pumps.

Some medications that are moved by these pumps include etoposide, paclitaxel, vinblastine, vincristine, vindesine, ketoconazole, itraconazole, amprenavir, indinavir, nelfinavir, saquinavir, cimetidine, ranitidine, diltiazem, verapamil, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.

Dosing considerations for Sweet Orange.

The following doses have been studied in scientific research:

BY MOUTH:
  • For high cholesterol: 750 mL sweet orange juice per day.
  • For high blood pressure and stroke prevention: Sweet orange juice products that provide at least 350 mg of potassium per serving and are low in sodium, saturated fat, and cholesterol are permitted by the FDA to make labeling claims that they might reduce the risk of developing high blood pressure and stroke.

Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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Report Problems to the Food and Drug Administration

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.



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