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Syphilis develops in four stages, each with a different set of symptoms.
During the primary stage of syphilis, a sore (chancre) that is usually painless develops at the site where the bacteria entered the body. This commonly occurs within 3 weeks of exposure but can range from 10 to 90 days. A person is highly contagious during the primary stage.
Secondary syphilis is characterized by a rash that appears 2 to 8 weeks after the chancre develops and sometimes before it heals. Other symptoms may also occur, which means that the infection has spread throughout the body. A person is highly contagious during the secondary stage.
A rash often develops over the body and commonly includes the palms of the hands and the soles of the feet.
The skin rash usually heals within 2 months. on its own without scarring. After healing, skin discoloration may occur. But even though the skin rash has healed, syphilis is still present and a person can still pass the infection to others.1
When syphilis has spread throughout the body, the person may have:
Latent (hidden) stage
If untreated, an infected person will progress to the latent (hidden) stage of syphilis. The latent stage is defined as the year after a person becomes infected. After the secondary-stage rash goes away, the person will not have any symptoms for a time (latent period). The latent period may be as brief as 1 year or range from 5 to 20 years.
Often during this stage, an accurate diagnosis can only be made through blood testing, the person's history, or the birth of a child with congenital syphilis.
A person is contagious during the early part of the latent stage and may be contagious during the latent period when no symptoms are present.
About 20 to 30 out of 100 people with syphilis have a relapse of the infection during its latent stage.2 A relapse means the person was symptom-free but then started having symptoms again. Relapses can occur several times.
When relapses no longer occur, a person is not contagious through contact. But a woman in the latent stage of syphilis may still pass the infection to her developing baby and may have a miscarriage or a stillbirth or give birth to a baby infected with congenital syphilis.
Tertiary (late) stage
This is the most destructive stage of syphilis. If untreated, the tertiary stage may begin as early as 1 year after infection or at any time during a person's lifetime. A person with syphilis may never experience this stage of the illness.
During this stage, syphilis may cause serious blood vessel and heart problems, mental disorders, blindness, nerve system problems, and even death. The symptoms of tertiary (late) syphilis depend on the complications that develop. Complications of this stage include:
Congenital syphilis refers to syphilis passed from a mother to her baby during pregnancy or during labor and delivery. The U.S. Centers for Disease Control and Prevention (CDC) and the U.S. Preventive Services Task Force strongly recommend that all pregnant women be screened for syphilis because of the severe consequences of being pregnant while infected or having a child born with congenital syphilis. Screening should be done:3, 4
Congenital syphilis increases the risk of fetal death and medical complications in newborns. Syphilis enters the fetal blood system through the placenta, causing infection in the newborn or death of the fetus. Symptoms of congenital syphilis include:
Because there are other conditions with similar symptoms, an accurate diagnosis is important for treatment.
eMedicineHealth Medical Reference from Healthwise
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