Pharmacy Author: Omudhome Ogbru, PharmD
Medical and Pharmacy Editor: Jay W. Marks, MD

GENERIC NAME: terconazole

BRAND NAME: Terazol, Zazole

DRUG CLASS AND MECHANISM: Terconazole is an anti-fungal cream and suppository used for treating vaginal yeast infections (Candida). It is related to several other anti-fungal drugs including fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), miconazole (Micatin, Monistat), and clotrimazole (Lotrimin). It prevents growth of yeast by preventing production of the membranes that surround the yeast cells. The FDA approved terconazole in December 1987.

PRESCRIPTION: Yes

GENERIC AVAILABLE: Yes

PREPARATIONS: Vaginal cream: 0.4 and 0.8%. Vaginal suppositories: 80 mg.

STORAGE: Terconazole should be stored at room temperature 15-30 C (59-86 F).

PRESCRIBED FOR: Terconazole is used for the treatment of vaginal infections caused by yeast.

DOSING: One applicator full of the 0.4% vaginal cream should be applied into the vagina at bedtime for 7 days. One applicator full of the 0.8% vaginal cream or one vaginal suppository should be applied at bedtime for 3 days.

DRUG INTERACTIONS: There are no known drug interactions with topical terconazole.

PREGNANCY: There are no adequate studies in pregnant women.

NURSING MOTHERS: It is not known if terconazole is secreted in breast milk.

SIDE EFFECTS: The most common side effects associated with terconazole are irritation, increased sensitivity and burning of the vulvae or vagina. Other side effects include headache, painful menstrual periods, aches, abdominal pain, fever, chills, and itching.

Reference: FDA Prescribing Information