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Thrombocytopenia (Low Platelet Count) (cont.)

1. Impaired platelet production

Low platelet count due to impaired production is generally due to problems with the bone marrow. Usually other blood cells (red and white) are also affected by some of these processes, and their numbers may be abnormal.

Some viral infections can cause low platelet count by affecting the bone marrow, for example,

Aplastic anemia (agranulocytosis) is the terminology for bone marrow failure leading to low platelet count usually associated with anemia (low red cell count) and leukopenia or leucopenia (low white cell count). Common causes of aplastic anemia include

  • infections (parvovirus, HIV);
  • some medications [chloramphenicol, gold, phenytoin (Dilantin), valproic acid (Depakene, Depakote, Depakote ER, Depacon);
  • radiation; or
  • congenital disorders (Fanconi's anemia).

Many chemotherapeutic drugs commonly cause bone marrow toxicity and thrombocytopenia.

Other causes of thrombocytopenia due to impaired bone marrow production of platelets include

Medically Reviewed by a Doctor on 7/13/2016

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