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Thyroid Medications (cont.)

Drug Interactions with L-thyroxine

L-thyroxine and other medications

Many other medications can affect the way L-thyroxine is absorbed from the gut. Notify your physician if you take L-thyroxine and any of the following medications:

  • ferrous sulfate [(Feostat, Ferrets, Hemocyte, Ircon, Nephro-Fer) or other iron supplements]
  • calcium carbonate [(Alka-Mints, Amitone, Cal-Gest, Calcarb, Calci Mix, Calci-Chew, Caltrate, Chooz, Maalox Antacid Barrier, Maalox Quick Dissolve, Maalox Quick Dissolve Maximum Strength, Mylanta Child, Nephro Calci, Os-Cal 500, Oysco 500, Oyst Cal 500, Oyster Calcium, Oyster Shell, Rolaids Sodium Free, Rolaids Soft Chew, Tums, Tums 500, Tums E-X, Tums Ultra) or other calcium supplements]
  • colestipol (Colestid, Colestid Flavored)
  • cholestyramine (Cholestyramine Light, Locholest, Locholest Light, Prevalite, Questran, Questran Light)
  • sodium polystyrene sulfonate (Kayexalate, Koinex)
  • Aluminum and magnesium containing antacids
  • sucralfate (Carafate) or simethicone (Alka-Seltzer Anti-Gas, Equalize Gas Relief Drops, Gas Aide, Gas-X, Gas-X Extra Strength, Gas-X Infant Drops, Gas-X Maximum Strength, Gas-X Thin Strips Cinnamon, Gas-X Thin Strips Peppermint, Gas-X Tongue Twisters Thin Strips Children's, Genasyme, Infantaire Gas Relief, Little Tummys, Maalox Anti-Gas, Maalox Anti-Gas Extra Strength, Mi-Acid Gas Relief, Mylanta Gas, Mylanta Gas Maximum Strength, Mylicon, Mytab Gas, Phazyme, Phazyme Maximum Strength, Phazyme Ultra, Phazyme-125, Phazyme-95)
  • raloxifene (Evista)
  • Estrogens can increase L-thyroxine requirements due to an increase in thyroid hormone binding proteins in the blood.
  • L-thyroxine can interfere with maintaining adequate blood levels of other medications. Notify your physician if you take L-thyroxine and any of the following medications:
    • digoxin (Digitek, Lanoxicaps, Lanoxin)
    • Anti-diabetic agents
    • theophylline (Elixophyllin, Theo-24, Theo-Time, TheoCap, Theochron, Uniphyl) and caffeine-containing agents
    • warfarin (Coumadin, Jantoven)
Medically Reviewed by a Doctor on 6/11/2014

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